IMIPOINT

IMIPOINT – Imipenem is a broad spectrum carbapenem antibiotic which is used for severe bacterial infections caused by susceptible organisms. Because imipenem is rapidly inactivated by renal dehydropeptidase I (DHP-1), it is given in combination with cilastatin, a DHP-I inhibitor which increases half-life and tissue penetration of imipenem. It works by stopping the growth of bacteria.

COMPOSITION:

Imipenem & Cilastatin 500 mg Injection

MODE OF ACTION:

Cause rapid bacterial cell death by covalently binding to penicillin-binding proteins (PBPs) involved in the biosynthesis of mucopeptides in bacterial cell walls. Bactericidal effects result through inhibition of cellular growth and division and the loss of cell wall integrity, eventually causing cell wall lysis. The primary target is PBP 2.

INDICATIONS

In Skin and Skin Structure Infections,Intra-abdominal Infections, Bacterial Septicemia, Urinary Tract Infections, Bacterial Meningitis, Lower Respiratory Tract Infections, Polymicrobial infection, Bone and joint infections, Endocarditis, Gynaecological infections

DOSAGE

500 mg IV every 6 hours or 1 g IV every 8 hours for fully susceptible organisms and 1 g IV every 6 hours for organisms with intermediate susceptibility. Clinical practice guidelines recommend imipenem; cilastatin for 4 to 7 days for severe or high-risk community-acquired infections or complicated health-care associated infections.

DISCLAIMER

This information is for the medical professionals & registered medical practitioners only. This product must be consumed with the valid prescription of registered medical practitioners.*Images/Pack are for representation purpose only.